Utrecht (The Netherlands), Cambridge (United States) – Respiratory device producer Vapotherm, Inc. announced its Initial Public Offering and listing on the NYSE exchange. Shares in the IPO are issued to institutional investors in the US and Europe, raising gross proceeds of $56 million. The offering was significantly oversubscribed. The total market capitalisation of Vapotherm will be $244 million at the introduction price and shares will trade under the ticker symbol VAPO.

The new funds enable Vapotherm to continue ramping sales of its Hi-VNI® technology in the US and Europe. Vapotherm’s Hi-VNI® treats patients in respiratory distress in the neo-natal intensive care unit (ICU), the adult ICU, the emergency department, post-acute care and for patients in hospice. The technology has been proven equivalent to the gold standard of non-invasive ventilation, however can be delivered without the need for a mask, providing patients with more comfort and flexibility in their care.

In addition to ramping sales with existing products, Vapotherm will use proceeds from the IPO to pursue an aggressive product development program which includes products which automate the delivery of oxygen based on feedback from a patient’s oxygen levels; and a portable device which has the potential to be used in expanded clinical settings, including the home.

Gilde Healthcare acted as lead investor in the Series B financing for Vapotherm and will remain represented on the board of Vapotherm post listing. During Gilde’s investment period Vapotherm tripled US and International revenues, established a highly specialized direct sales force, and dramatically increased gross margins.

Bank of America Merrill Lynch and William Blair acted as Joint Bookrunners in connection with the IPO. Canaccord Genuity acted as lead manager and BTIG acted as co-manager.

About Gilde Healthcare

Gilde Healthcare is a specialized European healthcare investor managing €1 billion across two business lines: a venture & growth capital fund and a private equity fund. Gilde Healthcare’s venture & growth capital fund invests in medtech, digital health and therapeutics. The portfolio companies are based in Europe and North America. Gilde Healthcare’s private equity fund invests in profitable European lower mid-market healthcare services companies with a focus on the Benelux and DACH-region. The portfolio consists of healthcare providers, suppliers of medical products and other service providers in the healthcare market. For more information, visit the company’s website at www.gildehealthcare.com

Stockholm, November 7, 2018

CCS Healthcare has entered into agreements to divest its Consumer Skincare business unit. CCS’s factory and contract manufacturing activities in Borlänge, Sweden, will be sold to Svenska Krämfabriken AB and the Group’s portfolio of skincare brands sold in Sweden, Norway, Finland and the UK will be acquired by Trimb Healthcare AB.

Following the divestments, CCS will be exclusively focused on hygiene and safety products in the professional business-to-business markets.

The transactions are expected to be completed in January 2019.

CCS Healthcare is a portfolio company of Segulah IV L.P.

For further information, please visit www.ccshc.com, www.segulah.com or contact:

Johan Möllerström, Investment Manager, Segulah Advisor AB, +46 72 543 79 11

Helsinki, Finland: 25 October 2018 – Nexstim Plc (NXTMH:HEX, NXTMS:STO), the targeted neuromodulation company developing, and marketing pioneering navigated personalised, non-invasive brain stimulation systems for the treatment of Major Depression Disorder (MDD), announces today that it has secured € 342 thousand in the form of future R&D loans from Business Finland. The funding is part of the ELASTRONICS project to develop wireless Electromyography (EMG) devices. ELASTRONICS (Enabling the Future of Wearable Electronics) is Finland’s largest research project for stretchable electronics technologies and production processes.

Palo Alto CA, USA: 12 October 2018 – Varian (NYSE: VAR) today announced the acquisition of privately-held software company Noona Healthcare, developer of a cloud-based, mobile service designed to capture cancer patient-reported outcomes (PROs). The Noona patient software app lets clinics capture PROs and communicate directly with patients. This acquisition expands Varian’s portfolio of cancer care solutions and fits the company’s long-term growth and value creation strategy.

Noona’s intuitive user interface creates an engaging experience for patients that encourages a high rate of adoption and adherence over long periods. Noona helps patients and care teams to proactively manage patient symptoms, which could lead to improved clinical outcomes and reduced hospitalization and emergency room visits.

As part of a succession plan, Gimv is investing in the two German companies Medi-Markt Homecare-Service GmbH and Medi Markt Service Nord Ost GmbH as well as a number of affiliated companies. These two leading service providers in incontinence care will continue to grow in the coming years as a newly formed group with the support of Gimv.

Antwerp / Munich / Mannheim / Isenbüttel, 18 October 2018, 07:30 am – European investment company Gimv has reached an agreement on the takeover of the majority of both Medi-Markt Homecare-Service GmbH based in Mannheim as well as Isenbüttel-based Medi Markt Service Nord Ost GmbH. These transactions are part of a succession plan for both companies. Gimv is thus expanding its Health & Care portfolio with a leading supplier of medical supplies in Germany, which is expected to continue to grow in the coming years. The remaining shares will be acquired by the newly appointed CEO of the Medi Markt Group,Markus Reichel. The transaction is subject to customary approval requirements and is expected to close within a few weeks.

The two companies and their affiliates, which together employ around 225 people, will form one group as of this transaction and will operate jointly under the Medi-Markt brand, headquartered in Mannheim. Markus Reichel, formerly managing director of Medi-Markt Homecare-Service GmbH, will become managing director of the new group and a co-shareholder. The companies are specialised mail-order providers of homecare supplies with a particular focus on absorbing incontinence. Further product groups include revulsive incontinence, diabetes control, stoma care, enteral nutrition, disinfection and protection as well as personal hygiene, supplying a total of c.12,000 different products. The companies distribute branded and private label products. Medi-Markt is one of the major providers in the country for incontinence aids and stoma care. The group has a combined annual turnover of more than 50 million EUR.

Medi-Markt supplies around 150,000 end-consumers annually. The majority of the products are reimbursed by health insurances, for whom Medi-Markt has been a reliable partner for many years.

“Together with our new growth partner Gimv, we want to further expand our product offering and advance into adjacent segments. We are also considering acquisitions of suitable companies,” explains Markus Reichel, Managing Director of Medi-Markt Homecare-Service GmbH and future CEO of the group. The business benefits from the demographic change since Medi Markt primarily caters an ageing population: today c. 7 million people suffer from incontinence in Germany. This number is expected to further increase to nine million over the next 20 years. “Medi-Markt’s high quality products and the company’s customer-centric approach enable many people to maintain a more independent lifestyle. At the same time, due to lean organizational structures, the company improves efficiency of care,” says Philipp v. Hammerstein, Partner at Gimv in the Health & Care segment in Munich. “We are l ooking forward to continuing the success story of these two leading specialists, while leveraging further potential related to the merger. Together with the experienced management team, we will focus on organic growth as well as on buy-and-build opportunities.”

The new investment marks Gimv’s seventh acquisition in the German-speaking healthcare market. This means that Gimv currently has 20 participations in companies in the healthcare and life sciences sector. This acquisition further underpins Gimv’s position as one of the most active European investors in the healthcare industry. The portfolio also includes several clinic and practice groups, medical technology and biotech companies.

Further details about the transaction will not be published.

17 October 2018 – Montagu Private Equity (“Montagu”) and Astorg (“Astorg”) today announce that Montagu has signed an agreement to sell Nemera (“the company”), a leading global manufacturer of drug administration systems for the pharmaceutical industry, to Astorg.

While committing to acquire the business in full, Astorg has offered Montagu the opportunity to reinvest as a partner in the next phase of Nemera’s growth, alongside its management team. Given the strength and growth potential of the company, Montagu has elected to exercise this option and form an equal partnership with Astorg to support Nemera’s management team in delivering the company’s ambitious development plans. Further terms of the transaction were not disclosed.

Headquartered in La Verpillière (France), Nemera designs, develops, and manufactures a full range of drug delivery devices including auto-injectors, inhalers, insulin pens, eye droppers and pumps from four state-of-the-art manufacturing sites in France, Germany and the US. Its products are sold to a variety of blue-chip customers from the pharmaceutical, biotech and generics industries. Nemera employs 1,950 full-time-equivalent employees.

With the support of Montagu, Nemera has grown its sales by 50% and increased by 25% its workforce since its carve out from Rexam PLC in 2014. The company has also further strengthened its world-class innovation centre and developed new services in line with its long-term commitment to improve patients’ lives and remain the partner of choice for its longstanding clients.

Following the transaction, Astorg will jointly control Nemera with Montagu, providing the financial resources and sector expertise required to support management’s ambitious growth plans, both organically and via carefully selected add-on acquisitions.

Marc Haemel, Nemera’s CEO, said “We are excited about our new partnership with Astorg and Montagu. We have been very impressed by Astorg’s in-depth understanding of our business, as well as their overall expertise in the healthcare space, which will help us fulfill our growth ambitions. We are also delighted to continue working with Montagu, who has significantly contributed to our success.

This transaction opens a promising new chapter for the company. It will allow us, with the support of Astorg and the continued commitment of Montagu, to build upon the company’s strengths and accelerate the development of our proprietary device portfolio and innovation capabilities, while also exploring additional value-creating opportunities.”

Completion of the transaction is subject to satisfactory clearance from relevant anti-trust authorities.

Astorg was advised by Citigroup and Latham & Watkins. Montagu was advised by HSBC, Morgan Stanley and Weil Gotshal.

Carlyle’s Global Healthcare Network and Experience to Help Expand the Business

Hangzhou, China – Global alternative asset manager The Carlyle Group (NASDAQ: CG) today announced that it, together with Meinian Onehealth Healthcare Holdings Co., Ltd., has invested in and become the single largest shareholder of, Adicon Holding Limited, one of the largest independent clinical laboratory (ICL) companies in China. Equity for the investment came from Carlyle Asia Partners V, Carlyle’s flagship US$6.55 billion fund focused on buyout and strategic investments across a range of sectors in Asia Pacific.

Established in 2004, Adicon operates 20 fully-owned diagnostic laboratories in China, offering diagnostic testing outsourcing services to more than 10,000 active customers, including hospitals, clinics and contract research organizations (CROs) in 28 provinces. China’s ICL industry is a fast-growing market, driven by growing healthcare expenditure, rising diagnostic demand, continued technology innovation and hospital cost control trends. As an ICL industry pioneer, Adicon has developed a scalable operation with high quality standards and a network of laboratories certified with China National Accreditation Services for Conformity Assessment (CNAS). Adicon’s comprehensive test portfolio includes a range of esoteric tests, addressing diverse customer demands.

Ling Yang, Managing Director of the Carlyle Asia Buyout advisory team, said, “We are excited to have the opportunity to invest in Adicon. Adicon is a platform company, which taps into the sustained growth and innovation in China’s healthcare market and helps the health system achieve cost savings. We have seen ICL leaders grow into substantial businesses in mature markets, and believe Adicon has similar potential. We look forward to working with our partners and the existing management team to build this company together.”

The Carlyle Group has invested more than US$11.5 billion of equity in more than 65 transactions in the global healthcare industry as of June 30, 2018. In Asia, Carlyle has invested approximately US$1.5 billion in 10 healthcare companies.

As one of the first and most active international private equity investors in China, Carlyle has adopted a local approach towards investments in China for two decades. Carlyle has invested more than US$8 billion of equity in nearly 100 private equity transactions across China through its US dollar and RMB investment vehicles as of June 30, 2018.

* * * * *

About The Carlyle Group

The Carlyle Group (NASDAQ: CG) is a global alternative asset manager with $210 billion of assets under management across 335 investment vehicles as of June 30, 2018. Carlyle’s purpose is to invest wisely and create value on behalf of its investors, many of whom are public pensions. Carlyle invests across four segments – Corporate Private Equity, Real Assets, Global Credit and Investment Solutions – in Africa, Asia, Australia, Europe, the Middle East, North America and South America. Carlyle has expertise in various industries, including: aerospace, defense & government services, consumer & retail, energy, financial services, healthcare, industrial, real estate, technology & business services, telecommunications & media and transportation. The Carlyle Group employs more than 1,625 people in 31 offices across six continents.

Web: www.carlyle.com

Videos: www.youtube.com/onecarlyle

Tweets: www.twitter.com/onecarlyle

Podcasts: www.carlyle.com/about-carlyle/market-commentary

Media Contacts:

Brian Zhou
+86 10 57067070
Brian.zhou@carlyle.com

Tammy Li
+852 2878 5236
Tammy.li@carlyle.com

Carlyle’s Global Healthcare Network and Experience to Help Expand the Business

Hangzhou, China – Global alternative asset manager The Carlyle Group (NASDAQ: CG) today announced that it, together with Meinian Onehealth Healthcare Holdings Co., Ltd., has invested in and become the single largest shareholder of, Adicon Holding Limited, one of the largest independent clinical laboratory (ICL) companies in China. Equity for the investment came from Carlyle Asia Partners V, Carlyle’s flagship US$6.55 billion fund focused on buyout and strategic investments across a range of sectors in Asia Pacific.

Established in 2004, Adicon operates 20 fully-owned diagnostic laboratories in China, offering diagnostic testing outsourcing services to more than 10,000 active customers, including hospitals, clinics and contract research organizations (CROs) in 28 provinces. China’s ICL industry is a fast-growing market, driven by growing healthcare expenditure, rising diagnostic demand, continued technology innovation and hospital cost control trends. As an ICL industry pioneer, Adicon has developed a scalable operation with high quality standards and a network of laboratories certified with China National Accreditation Services for Conformity Assessment (CNAS). Adicon’s comprehensive test portfolio includes a range of esoteric tests, addressing diverse customer demands.

Ling Yang, Managing Director of the Carlyle Asia Buyout advisory team, said, “We are excited to have the opportunity to invest in Adicon. Adicon is a platform company, which taps into the sustained growth and innovation in China’s healthcare market and helps the health system achieve cost savings. We have seen ICL leaders grow into substantial businesses in mature markets, and believe Adicon has similar potential. We look forward to working with our partners and the existing management team to build this company together.”

The Carlyle Group has invested more than US$11.5 billion of equity in more than 65 transactions in the global healthcare industry as of June 30, 2018. In Asia, Carlyle has invested approximately US$1.5 billion in 10 healthcare companies.

As one of the first and most active international private equity investors in China, Carlyle has adopted a local approach towards investments in China for two decades. Carlyle has invested more than US$8 billion of equity in nearly 100 private equity transactions across China through its US dollar and RMB investment vehicles as of June 30, 2018.

* * * * *

About The Carlyle Group

The Carlyle Group (NASDAQ: CG) is a global alternative asset manager with $210 billion of assets under management across 335 investment vehicles as of June 30, 2018. Carlyle’s purpose is to invest wisely and create value on behalf of its investors, many of whom are public pensions. Carlyle invests across four segments – Corporate Private Equity, Real Assets, Global Credit and Investment Solutions – in Africa, Asia, Australia, Europe, the Middle East, North America and South America. Carlyle has expertise in various industries, including: aerospace, defense & government services, consumer & retail, energy, financial services, healthcare, industrial, real estate, technology & business services, telecommunications & media and transportation. The Carlyle Group employs more than 1,625 people in 31 offices across six continents.

Web: www.carlyle.com

Videos: www.youtube.com/onecarlyle

Tweets: www.twitter.com/onecarlyle

Podcasts: www.carlyle.com/about-carlyle/market-commentary

Media Contacts:

Brian Zhou
+86 10 57067070
Brian.zhou@carlyle.com

Tammy Li
+852 2878 5236
Tammy.li@carlyle.com